Low Dose Lead and CNS Deficits

Toxicity of lead at low dose.

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

The central nervous system (CNS) is the major area that is affected by aging. Alzheimer's disease (AD), Parkinson's disease (PD), brain cancer, and stroke are the CNS diseases that will cost trillions of dollars for their treatment. Achievement of appropriate blood-brain barrier (BBB) penetration is often considered a significant hurdle in the CNS drug discovery process. On the other hand, BBB ...

Perinatal asphyxia: CNS development and deficits with delayed onset

Perinatal asphyxia constitutes a prototype of obstetric complications occurring when pulmonary oxygenation is delayed or interrupted. The primary insult relates to the duration of the period lacking oxygenation, leading to death if not re-established. Re-oxygenation leads to a secondary insult, related to a cascade of biochemical events required for restoring proper function. Perinatal asphyxia...

Frontal cognitive impairments and saccadic deficits in low-dose MPTP-treated monkeys.

There is considerable overlap between the cognitive deficits observed in humans with frontal lobe damage and those described in patients with Parkinson's disease. Similar frontal impairments have been found in the 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP) primate model of Parkinsonism. Here we provide quantitative documentation of the cognitive, oculomotor, and skeletomotor dysfuncti...

بررسی تاثیر آسپرین low-dose (75mg/day) در پیشگیری از پراکلامپسی

خطرات پره اکلامپسی و متعاقب آن اکلامپسی به خوبی مشخص می باشد. آسپرین low-dose با کاهش انتخابی ترومبوکسان a2 سبب غلبه پروستاسیکلین شده و به این طریق از پره اکلامپسی و عوارض آن جلوگیری می نماید. در این مطالعه 150 خانم حامله در معرض پره اکلامپسی به طور رندوم به دو گروه دریافت کننده آسپرین (60 نفر) و دریافت کننده آسپرین (90 نفر) تقسیم شدند. پراکلامپسی فقط در 2 نفر از گروه آسپرینی دیده شد(3/3